Game publishers and developers do not support the use of No-CD patches. You game may not work correctly with one.
How No-CD Patches Work
When games are launched they usually look to make sure the CD is in the drive. Usually files aren't being accessed to play the game, but instead to make sure you have a copy of it. No-CD patches take care of this problem.
Gamers will edit the exe file of the game, and take out the command lines to verify the CD is in the CD-drive. When you download a no-cd patch, you'll probably download a zip file with an exe file and text instructions.
Keeping Reading - Where to Download No-CD Patches